Table 4.
Association between Body Mass Index Category and Stroke Events Stratified by Sex in Non-Hypertensive Participants.
| Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|
| Normal Weight (n = 844,494) |
Underweight (n = 57,301) |
Overweight (n = 257,245) |
Obesity (n = 40,618) |
Normal Weight (n = 753,667) |
Underweight (n = 172,343) |
Overweight (n = 109,299) |
Obesity (n = 25,071) |
|
| Total Stroke | ||||||||
| No. of events | 6508 | 320 | 2203 | 279 | 4730 | 943 | 793 | 153 |
| Incidence | 22.0 (21.5–22.6) |
18.3 (16.4–20.5) |
24.9 (23.8–25.9) |
22.1 (19.7–24.9) |
20.8 (20.2–21.4) |
18.1 (16.9–19.2) |
25.3 (23.6–27.1) |
22.9 (19.5–26.8) |
| Model 1 | 1 (Reference) |
0.84 (0.75–0.94) |
1.13 (1.08–1.19) |
1.02 (0.90–1.15) |
1 (Reference) |
0.87 (0.81–0.93) |
1.22 (1.13–1.31) |
1.10 (0.94–1.30) |
| Model 2 | 1 (Reference) |
0.97 (0.87–1.09) |
1.14 (1.09–1.20) |
1.32 (1.17–1.49) |
1 (Reference) |
0.99 (0.92–1.06) |
1.13 (1.05–1.22) |
1.26 (1.07–1.48) |
| Model 3 | 1 (Reference) |
0.99 (0.88–1.10) |
1.09 (1.04–1.15) |
1.20 (1.06–1.35) |
1 (Reference) |
1.00 (0.93–1.08) |
1.09 (1.01–1.18) |
1.20 (1.02–1.41) |
| Ischemic Stroke | ||||||||
| No. of events | 5785 | 253 | 1958 | 249 | 4222 | 840 | 709 | 142 |
| Incidence | 19.6 (19.1–20.1) |
14.5 (12.8–16.4) |
22.1 (21.1–23.1) |
19.8 (17.5–22.4) |
18.6 (18.0–19.2) |
16.1 (15.0–17.2) |
22.6 (21.0–24.4) |
21.2 (18.0–25.0) |
| Model 1 | 1 (Reference) |
0.75 (0.66–0.85) |
1.13 (1.08–1.19) |
1.02 (0.90–1.16) |
1 (Reference) |
0.87 (0.80–0.93) |
1.22 (1.13–1.32) |
1.15 (0.97–1.36) |
| Model 2 | 1 (Reference) |
0.87 (0.76–0.98) |
1.15 (1.09–1.21) |
1.34 (1.18–1.52) |
1 (Reference) |
0.99 (0.92–1.07) |
1.13 (1.04–1.22) |
1.31 (1.11–1.55) |
| Model 3 | 1 (Reference) |
0.88 (0.77–1.00) |
1.09 (1.04–1.15) |
1.21 (1.07–1.38) |
1 (Reference) |
1.01 (0.94–1.09) |
1.09 (1.00–1.18) |
1.24 (1.05–1.47) |
| Hemorrhagic Stroke | ||||||||
| No. of events | 902 | 78 | 316 | 37 | 643 | 135 | 110 | 12 |
| Incidence | 3.0 (2.8–3.2) |
4.5 (3.6–5.6) |
3.6 (3.2–4.0) |
2.9 (2.1–4.0) |
2.8 (2.6–3.0) |
2.6 (2.2–3.1) |
3.5 (2.9–4.2) |
1.8 (1.0–3.1) |
| Model 1 | 1 (Reference) |
1.48 (1.18–1.87) |
1.17 (1.03–1.33) |
0.98 (0.71–1.37) |
1 (Reference) |
0.91 (0.76–1.10) |
1.25 (1.02–1.53) |
0.64 (0.36–1.13) |
| Model 2 | 1 (Reference) |
1.68 (1.34–2.12) |
1.17 (1.03–1.33) |
1.16 (0.84–1.61) |
1 (Reference) |
1.01 (0.84–1.21) |
1.17 (0.96–1.43) |
0.70 (0.39–1.23) |
| Model 3 | 1 (Reference) |
1.66 (1.32–2.10) |
1.15 (1.01–1.31) |
1.12 (0.81–1.57) |
1 (Reference) |
0.99 (0.83–1.20) |
1.18 (0.97–1.45) |
0.71 (0.40–1.27) |
The incidence rate was per 10,000 person-years. Model 1 = Unadjusted, Model 2 = Adjusted for age, Model 3 = Adjusted for age, diabetes mellitus, dyslipidemia, cigarette smoking, alcohol consumption, and physical inactivity.