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. 2021 Jul 12;14(7):667. doi: 10.3390/ph14070667

Table 4.

Mass-spectrometry analysis of proteins bound to CPP-pDNA nanoparticles from human serum at higher level. Fifteen most abundant proteins in protein corona are listed. Data represents two independent experiments and three technical replicates of each with ±SEM, compared to b-pGL3. * p-Value < 0.05, ** p-Value < 0.005, *** p-Value < 0.0005.

Protein Group b-pGL3 PF14 + b-pGL3
Serum albumin 44.5 ± 0.5 91.5 ± 0.5 ***
Serotransferrin 15.5 ± 0.5 76.0 ± 0.0 **
α-2-macroglobulin 20.0 ± 1.0 89.5 ± 1.5 *
α-1-antitrypsin 23.0 ± 0.0 33.5 ± 1.5
Apolipoprotein A-I 15.5 ± 0.5 30.0 ± 0.0 *
Haptoglobin 16.0 ± 1.0 27.5 ± 0.5
Complement component 3 16.0 ± 1.0 119.5 ± 0.5 **
Ig γ-1 chain C region 9.0 ± 1.0 15.0 ± 0.0
Ig γ-3 chain C region 6. ± 0.5 17.5 ± 0.5
Ig κ-chain C region 7.0 ± 0.0 12.0 ± 0.0
α-1-acid glycoprotein 1 5.0 ± 0.0 12.0 ± 0.0 ***
Ig α-1 chain C region 7.0 ± 1.0 20.0 ± 0.0 *
Complement component 4-B 4.0 ± 0.0 78.0 ± 1.0 **
Hemopexin 0.0 ± 0.0 25.0 ± 0.0 ***
Apolipoprotein A-II 5.5 ± 0.5 8.0 ± 0.0