Table 1.
The effect of three macrolide antibiotics on the ECG parameters in healthy rats and MI model rats.
| Groups | PR Interval (ms) |
QT Interval (ms) |
HR (Beat/min) |
|---|---|---|---|
| Vehicle | 40.1 ± 1.79 | 88.6 ± 2.37 | 369.3 ± 8.65 |
| Azith | 44.3 ± 1.50 * | 93.8 ± 1.05 * | 379.3 ± 2.56 * |
| Clarith | 43.9 ± 2.2 * | 93.6 ± 137 * | 375.3 ± 1.44 * |
| Eryth | 44.2 ± 1.89 * | 94.6 ± 1.65 * | 381.1 ± 2.34 * |
| MI+ Vehicle | 46.4 ± 1.90 | 94.2 ± 2.15 | 388.1 ± 8.21 |
| MI + Azith | 48.8 ± 5.22 | 95.6 ± 3.37 | 389.9 ± 80.69 |
| MI + Clarith | 49.6 ± 2.32 a | 99.3 ± 2.91 a | 425.5 ± 45.63 a |
| MI + Eryth | 50.1 ± 3.3 a | 98.2 ± 1.71 a | 426.6 ± 36.33 a |
Data are mean ± standard deviation, * Different from the vehicle group, a Different from the MI + Azith group at p-value less than 0.05, (n = 4–6).