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. 2021 Jun 29;10(7):818. doi: 10.3390/pathogens10070818

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of cumin-EO treatment on the clinical outcome of C. jejuni infection in IL-10^-/- mice. C. jejuni infected secondary abiotic IL-10^-/- mice received either placebo (PLC, grey circles) or cumin-EO (white circles) from d2 until d6 post-infection. (A) The overall clinical conditions of mice were quantitatively determined on d6 post-infection, by using a cumulative clinical scoring system (see methods) assessing the sum of the individual scores for (B) wasting symptoms, (C) diarrhea, and (D) fecal blood. Naive mice (open diamonds) constituted untreated and uninfected controls. Numbers of included mice are given in parentheses. Black bars indicate medians. Significance levels (p values) were determined with data pooled from four independent experiments using the Kruskal–Wallis test and Dunn’s post-correction.