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. 2021 Jul 9;14(7):659. doi: 10.3390/ph14070659

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic of experiment protocol. Mice were divided into five groups; a non-stress group administered 0.5% sodium carboxymethyl cellulose (SCMC) daily for 6 weeks (non-stress), and four UCMS groups. The UCMS groups were exposed to various stressors for 6 weeks. The UCMS mice were divided into four groups which were administered 0.5% SCMC (UCMS + vehicle), 20 mg/kg i.p. imipramine (UCMS + IMP20), 100 mg/kg p.o. KBD (UCMS + KBD100), or 500 mg/kg p.o. KBD (UCMS + KBD500) daily from week 3. The sucrose preference test was performed every week during the UCMS procedure. The forced swimming test (FST), tail suspension test (TST), and assessment of locomotor activity were conducted after week 6. After finishing the behavioral tests, all animals were decapitated, and their brains were collected for neurochemical assessment.