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. 2021 Jul 17;13(7):2448. doi: 10.3390/nu13072448

Figure 1.

Figure 1

To determine the effect of asiatic acid (AA) in vitro in 20 ng/mL IFN-γ + TNF-α-treated HaCaT cells pretreated with 5–20 μg/mL AA and in a 1% 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) animal model. AD mice were randomly divided into six groups (n = 7 per group). DNCB promoted AD skin lesions in the mice. Briefly, 200 µL 0.25% DNCB was applied to each mouse’s ear and, after 4 d, application was repeated once every 2 d for 18 d. AA (30 and 75 mg/kg/d) was orally administered. The AA-H mice were orally administered 75 mg/kg/d AA. Prednisolone was orally administered (5 mg/kg/d).