Table 1.

COVID-19 drug regimens and their classification as CYP inhibitors and inducers.

Drug	Substrate	CYP Inhibitor	CYP Inducer
Remdesivir [15,18,24]	CES, CYP3A4, CYP2C8, CYP2D6, P-gp, OATP1B1	CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4	CYP1A2, CYP2B6
Dexamethasone [43]	CYP3A4, P-gp	CYP3A4	CYP3A4
Chloroquine/Hydroxychloroquin [44]	CYP2C8, CYP3A4/5, CYP2D6	CYP2D6	None reported
Azithromycin [45]	CYP3A4, P-gp	None reported	None reported
Lopinavir/Ritonavir [46]	CYP1A2, CYP2B6, CYP2D6, CYP3A4, P-gp	CYP2D6, CYP3A4	CYP1A2, CYP2B6, CYP2C19, CYP2C9
Ivermectin [47,48]	CYP3A4, P-gp	CYP2C9, CYP2D6, CYP2C19, CYP3A4	CYP1A, 2B and 3A
Anakinra [49]	None reported	None reported	None reported
Interferon beta [50,51]	None reported	CYP1A2	None reported