Figure 5.

Cellular response and protection upon FMDV challenge in VLP/Adenovirus prime boost vaccination regimes. (A) ELISPOT analysis of IFNγ-producing splenocytes in response to stimulation with recombinant protein FMDV 3D. Shown are means + SD for each group of 5 mice as indicated and significant differences among groups indicated by ** (p < 0.01), ns: no significant differences. (B) Groups of mice as shown where challenged with FMDV_CS8c1 by intraperitoneal inoculation upon completion of the vaccination schedule and survival over an 8-day period is represented.