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Binding of the trastuzumab-DNA mimic conjugate to breast (MCF-7, T-47D, SK-BR-3) and ovarian (SK-OV-3) cancer cells expressing various levels of HER2 was evaluated by FACS. Cells were incubated with 10 µg/mL of the trastuzumab-DNA mimic conjugate (ADC), trastuzumab (TZ) or the irrelevant 13R4 antibody for 1 h. Then, cells were washed with cold PBS, trypsinized and 1 × 106 cells were analyzed by FACS. Untreated cells were used as a control.
