Figure 4.

Effects of the trastuzumab-DNA mimic conjugate on cell growth. Cells were incubated with indicated concentrations of the trastuzumab-DNA mimic 4 (ADC), trastuzumab (TZ), or equivalent concentrations of the DNA mimic corresponding to a DAR 3 (DNA mimic) for 72 h, and cell growth was evaluated using the sulforhodamine B assay as described in Materials and Methods. Results are expressed as percentages of cell growth relative to untreated cells and are the mean ± sd of three independent experiments.