Table 5.

Dissolution data model fitting results for the employed drug release kinetic models.

Release Fitting Model	PLA		PBAd		PLA/PBAd
					95/5		90/10		75/25		5050
	R2	k-Constant	R2	k-Constant	R2	k-Constant	R2	k-Constant	R2	k-Constant	R2	k-Constant
Fast-release phase
Zero order	0.60	2.77 d−1	0.77	8.03 d−1	0.68	4.61 d−1	0.67	4.32 d−1	0.82	5.54 d−1	0.80	7.43 d−1
First order	<0.01	0.09 d−1	0.58	0.20 d−1	0.16	0.11 d−1	0.12	0.10 d−1	0.54	0.11 d−1	0.57	0.17d−1
Higuchi	0.31	14.84 d−1	0.93	25.45 d−1/2	0.83	16.45 d−1/2	0.81	16.03 d−1/2	0.94	16.67 d−1/2	0.93	22.95 d−1/2
Hixson–Crowell	<0.01	0.05 d−1	0.69	0.06 d−1	0.08	0.03 d−1	0.04	0.03 d−1	0.48	0.03 d−1	0.49	0.05 d−1
Korsmeyer–Peppas	0.99	21.90 d−n	0.99	29.93 d−n	0.99	20.66 d−n	0.98	20.35 d−n	0.98	19.06 d−n	0.98	26.70 d−n
Slow-release phase
Zero order	0.77	4.20 d−1	0.98	3.91 d−1	0.84	3.98 d−1	0.89	4.02 d−1	0.87	4.08 d−1	0.93	3.42 d−1
First order	0.69	0.07 d−1	0.71	0.03 d−1	0.75	0.06 d−1	0.77	0.06 d−1	0.74	0.06 d−1	0.80	0.04 d−1
Higuchi	0.60	16.64 d−1/2	0.53	10.58 d−1/2	0.66	16.08 d−1/2	0.66	15.21 d−1/2	0.62	14.60 d−1/2	0.66	12.79 d−1/2
Hixson–Crowell	0.74	0.02 d−1	0.76	0.01 d−1	0.81	0.02 d−1	0.83	0.02 d−1	0.79	0.01 d−1	0.85	0.01 d−1
Korsmeyer–Peppas	0.76	5.21 d−n	0.98	0.61 d−n	0.83	4.99 d−n	0.88	3.89 d−n	0.85	3.31 d−n	0.93	2.62 d−n