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. 2021 Jun 24;13(7):940. doi: 10.3390/pharmaceutics13070940

Figure 5.

Figure 5

(A) Schematic diagram of photo-controlled bacterial therapy. Reproduced from [85], 2018, Springer Nature. (B) Preparation procedure of YB1–INPs. Synthesized INPs with single-step sonication were attached to YB1 through amide bonds. YB1–INPs with hypoxia-targeting and photothermal-assisted bioaccumulation for tumor penetrative therapy. After migration into tumor hypoxic cores and subsequent irradiation with a NIR laser, the loosening of the tumor tissue and tumor lysis generate bacteria-attracting nutrients, which further enhances the accumulation and coverage of YB1–INPs in large solid tumors. Ultimately, the enriched YB1–INPs under NIR laser irradiation completely ablated the large solid tumor without relapse. Reproduced with permission from [86], 2019, Elsevier. (C) The scheme of a bacteria-based Fenton-like bioreactor and its chemodynamic therapy process for antitumor therapy. Reproduced with permission from [87], 2019, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.