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. 2021 Jul 13;13(7):1071. doi: 10.3390/pharmaceutics13071071
AFM atomic force microscopy
API active pharmaceutical ingredient
CH cholesterol
CMAs Critical Material Attributes
CPPs Critical Process Parameters
CQAs Critical Quality Attributes
DLS dynamic light scattering
DoE Design of Experiments
DPPE-PEG2000 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)
DS Design Space
DSC differential scanning calorimetry
DSPE–PEG2000 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt)
dTG derivative thermogravimetry
EMA European Medicine Agency
FT-IR Fourier-transform infrared spectroscopy
ICH International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use
LUV large unilamellar vesicles
PBS phosphate-buffered saline
PC L-α-phosphatidylcholine
PdI Polydispersity Index
PE phosphatidylethanolamine
PEG polyethylene glycol
QbD Quality by Design
QTPP Quality Target Product Profile
R&D Research and Development
RA Risk Assessment
Tc gel to liquid-crystalline phase transition temperature
Tg glass transitions temperature
TGA thermogravimetric analysis
Tm phase transition temperature