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In vitro–in vivo relationship disconnect between in vitro solubility (A) and clinical food-effect data in furosemide (B). The 42% decreased AUC in fed versus fasted state is not explained by furosemide solubility data, which shows a 70-fold higher solubility in the fed state (pH 5.0) compared to fasted state (pH 1.6) in simulated gastric fluid (FeSSGF and FaSSGF, respectively).
