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Workflow of systematic analysis of 311 drugs followed by segregation of drugs in four groups based on dose number and efflux transport saturation index. Dose number and efflux transport saturation indices were calculated based on Equations (2) and (3), respectively. Groups 1 and 3 are solubility-limited (log dose number ≥ 1), and groups 2 and 4 are permeability-limited (log dose number < 1).
