Figure 4.
The association of diet-type on the magnitude of negative food-effect. The change in Cmax (A) and AUC (B) were compared for the high-affinity efflux transporter substrates, i.e., omadacycline, eltrombopag, indinavir, and asciminib, with known food-effect data following a high- and low-fat diet. The longer gastric emptying time caused by the high-fat diet is a likely mechanism of the increased efficiency of efflux transport. ** and *** indicate p < 0.01 and p < 0.001, respectively (paired t-test).