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. 2021 Jun 24;13(7):946. doi: 10.3390/pharmaceutics13070946

Figure 8.

Figure 8

The cleavage of supercoiled pBR322 DNA (62.5 µg/mL) by the complexes at 37 °C in 5 mM Tris HCl, 50 mM NaCl buffer. (A)—DNA incubated with compounds (1) and (2), respectively; c, control line—DNA in buffer (5 mM Tris HCl, 50 mM NaCl) (1:1), 1000–15.6 µg/mL, decreasing concentration of compounds (1) and (2). (B)—DNA incubated with H2O2 (100 µM), compound (1) (500 µg/mL) + H2O2 (100 µM), and (2) (500 µg/mL) + H2O2 (100 µM), respectively; c, control line—DNA in buffer (5 mM Tris HCl, 50 mM NaCl) (1:1), 5–120 min, time of incubation. (C)—DNA incubated with H2O2 (100 µM), compound (1) (62.5 µg/mL) + H2O2 (100 µM) and (2) (62.5 µg/mL) + H2O2 (100 µM), respectively; c, control line—DNA in buffer (5 mM Tris HCl, 50 mM NaCl) (1:1), 5–120 min, time of incubation.