Figure 2.

Characteristics of the modelling approaches developed in immuno-oncology. Dashed black arrows indicate activation, solid blocked arrows indicate inhibition, solid sharped arrows indicate transit between compartments, and $\varnothing$ indicates death. Colored compartments are used to depict modeling approaches that are contrary to those in the grey compartments. Abbreviations: IL—Interleukin, NR—non-responders, SD—stable disease, PR—partial response, CR—complete response, NK—natural killer, TIL—Tumor infiltrate lymphocyte, CTL—cytotoxic T lymphocytes, ADT—androgen deprivation therapy, CIK—cytokine-induced killer cell, BCG—Bacillus Calmette Guérin, ORR—overall response rate, OS—overall survival, PSA—prostate specific atnigen, NSCLC—non-small cell lung cancer, CLL—chronic lymphocytic leucemia, TCE—T-cell-engager, CAR—chimeric antigen receptor.