Figure 3.

Middle-out approach model representation. The equations that are common to most of the middle-out approaches are described in the figure. Dashed black arrows indicate activation, solid blocked arrows indicate inhibition, solid sharped arrows indicate transit between compartments, and $\varnothing$ indicates death. Colored compartments are used to depict modeling approaches that are contrary those in the grey compartments. Abbreviations: NK—natural killer, nTCD4—naïve CD4 cells, nTCD8—naïve CD8 cells, Treg—regulatory T cells, Thelper—Helper T cells, aCD8—activated CD8 T cells, mAPC—mature antigen presenting cells, APC—immature antigen presenting cells, TS—tumor size, L—lymphocytes. Other parameters are presented in Table 2.