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Effects of raloxifene (RLX)-loaded SLNs on (a) Caco-2 cellular uptake, (b) P-gp efflux using the Chemicon MDR dye efflux assay kit, and (c) pharmacokinetic properties of RLX (red curve: RLX-loaded SLNs and blue curve: RLX suspension). *** p < 0.001, ns, not significant. Reprinted by permission from Springer Nature, Drug Delivery and Translational Research [87], Copyright © 2021.
