Table 1.
Composition and characterizations of desmopressin acetate loaded elastic liposomes.
| Formulation Code | * PC: S Ratio (%) | Surfactant Type |
Hydrating Media | Mean Size (nm) | ** PDI | Elasticity | % EE |
|---|---|---|---|---|---|---|---|
| DELT90 | 90 (90:10) | Tween 80 | PBS | 335.6 ± 22.81 | 0.47 | 15.2 ± 2.1 | 23.6 ± 2.8 |
| DELT70 | 70 (70:30) | Tween 80 | PBS | 203.9 ± 10.02 | 0.36 | 27.1 ± 2.7 | 32.6 ± 3.1 |
| DELT60 | 60 (60:40) | Tween 80 | PBS | 178.1 ± 9.54 | 0.28 | 36.3 ± 4.2 | 40.2 ± 4.8 |
| DELS90 | 90 (90:10) | Span 80 | PBS | 212.7 ± 23.22 | 0.47 | 25.8 ± 2.2 | 28.8 ± 5.1 |
| DELS70 | 70 (70:30) | Span 80 | PBS | 169.5 ± 11.34 | 0.41 | 39.9 ± 3.7 | 53.8 ± 5.9 |
| DELS60 | 60 (60:40) | Span 80 | PBS | 156.6 ± 10.54 | 0.23 | 58.0 ± 2.7 | 24.7 ± 6.2 |
| DSC90 | 90 (90:10) | SC | PBS | 209.6 ± 18.5 | 0.21 | 35.2 ± 5.7 | 47.8 ± 4.6 |
| DSC70 | 70 (70:30) | SC | PBS | 149.8 ± 14.8 | 0.21 | 58.2 ± 6.8 | 73.9 ± 7.1 |
| DSC60 | 60 (60:40) | SC | PBS | 111.7 ± 9.09 | 0.11 | 66.7 ± 8.1 | 77.4 ± 6.9 |
| Liposome | PC: C: Span 80 (75: 10: 15) | PBS | 276.8 ± 20.7 | 0.29 | 11.1 ± 0.5 | 32.0 ± 1.1 | |
Values are represented as mean ± SD (n = 3), % EE = percent entrapment efficiency, ** PDI = polydispersity index, * PC: S = phosphatidylcholine, and S = surfactant, PBS (pH 5.5) = (0.1 M HCl and 0.154 M sodium chloride), C = cholesterol, SC = Sodium cholate.