Table 3.
Summary of THCL and KTF release experiments evaluating the effect of hydrocarbon chain length of fatty acid. Data are presented as mean ± standard deviation with n = 3.
| Contact Lens | Fatty Acid Loaded | Tetracaine Hydrochloride | Ketotifen Fumarate | ||
|---|---|---|---|---|---|
| Amount of Drug Uptake (µg/Lens) | Time for 70% Cumulative Drug Release (h) | Amount of Drug Uptake (µg/Lens) | Time for 70% Cumulative Drug Release (h) | ||
| ACUVUE TruEye | Control | 120.3 ± 4.0 | 3.34 ± 0.21 | 211.1 ± 13.0 | 5.41 ± 1.35 |
| C8 | 46.2 ± 3.6 | 1.47 ± 0.14 | 117.9. ± 11.0 | 4.62 ± 0.40 | |
| C10 | 140.9 ± 3.1 | 2.76 ± 0.79 | 237.7 ± 12.0 | 6.10 ± 0.74 | |
| C12 | 356.3 ± 10.6 | 27.5 ± 3.56 | 540 ± 21.3 | 62.9 ± 5.66 | |
| C14 | 349.2 ± 15.0 | 45.4 ± 3.73 | 516.4 ± 4.1 | 79.4 ± 3.55 | |
| C18 | 330.6 ± 17.8 | 25.1 ± 1.58 | 502.3 ± 39.2 | 101.8 ± 41.4 | |
| Dailies Total | Control | 99.4 ±1.7 | 1.86 ± 0.13 | 152.8 ± 7.1 | 2.37 ± 0.48 |
| C8 | 47.7 ± 5.0 | 1.73 ± 0.05 | 92.3. ± 13.2 | 2.60 ± 0.11 | |
| C10 | 104.4 ± 12.3 | 1.79 ± 0.15 | 172.3 ± 3.0 | 1.95 ± 0.04 | |
| C12 | 255.0 ± 15.3 | 9.90 ± 1.09 | 390.9 ± 26.0 | 24.7 ± 3.54 | |
| C14 | 268.7 ± 11.1 | 20.0 ± 5.68 | 339.5 ± 15.9 | 22.3 ± 2.89 | |
| C18 | 230.6 ± 24.5 | 11.1 ± 6.31 | 321.0 ± 23.9 | 21.7 ± 6.60 | |