Figure 4.
EB extravasation in the right brain (FUS-exposed site). (a) Distribution of FUS-induced BBB opening indicated by the extravasation of EB. (b) The amount of EB extravasation in the right brain. The EB was injected into the mice tail vein (100 μg/g·b.w.). After 5 min, they were injected with NBs (100 μg/mouse) and exposed to FUS with 30% duty (sec) for 90 s. After 3 h, the right brain was collected. The bars show the mean and S.D. (n = 3–6). * indicates p < 0.05 using a one-way ANOVA with Tukey’s post-hoc test.