Table 1.

Treatments that increase TRAIL sensitivity.

Treatment	Cancer	Effect	Reference
Goniothalamin plus TRAIL	Colorectal cancer	Enhance cytotoxicity and apoptosis	[35]
Icaritin plus TRAIL	Glioblastoma	Enhance apoptosis by c-FLIP downregulation and inhibition of NF-κB activity	[36]
Micelle-in-liposomes with piperlongumine plus TRAIL	Prostate cancer	Increase sensitization to TRAIL apoptosis in cancer cells	[37]
Silibinin plus TRAIL	Glioma	Enhance apoptosis by upregulation of DR5 and downregulation of cFLIP and survival	[38]
SH122 plus TRAIL	Prostate cancer	Enhanced TRAIL-induced apoptosis via D5R and the mitochondrial pathway	[39]
MSC/dTRAIL-TK gene therapy	Renal cell carcinoma	Enhance sensitization to TRAIL and increase apoptosis	[40]
Duloxetine plus TRAIL	Lung cancer	Enhance apoptosis of tumor cells through inhibition of autophagy	[41]
3-Methyladenine and chloroquine plus TRAIL	Malignant melanoma and osteosarcoma	Enhance pro-apoptotic mitochondrial pathway of tumor cells through inhibition of autophagy	[42]
Adenovirus-p53 plus TRAIL	Ovarian and nasopharyngeal squamous cancer	Overexpression of DR5 receptor in cancer cells to increase apoptosis by TRAIL	[43]
Adenovirus E1A plus adenovirus-hTRAIL	Hepatic cancer	Enhance apoptosis by upregulation of TRAIL receptors	[44]
MiR-760 plus TRAIL	Non-small-cell lung cancer	Enhance apoptosis by targeting FOXA1	[45]