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. 2021 Jul 6;13(7):1024. doi: 10.3390/pharmaceutics13071024

Table 3.

Suggestive list of biosurfactants to be used in nanoemulsion.

Biosurfactant Class Source Organism Cosmetic Properties Chemical Structure CMC Reference
Rhamnolipid Glycolipid Bacteria Pseudomonas aeruginosa This biosurfactant is a good emulsifying agent. It also has antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Micrococcus luteus, and monocytogenes. It also is known for its skin-repairing abilities by reduced fibrosis. graphic file with name pharmaceutics-13-01024-i001.jpg 5–50 mg/L [142]
Mannosylerthriol lipid Glycolipid Fungi Pseudozyma and Ustilago This biosurfactant has antiaging properties, particularly in the recovery of skin cells that have been damaged by UV radiation. It also exhibits antimicrobial activities. graphic file with name pharmaceutics-13-01024-i002.jpg 1.50–100 mg/L [143]
Trehalose lipid Glycolipid Bacteria Mycobacterium, Rhodococcus, Arthrobacter, Nocardia, and Gordonia The biosurfactant can reduce the interfacial tension and increase pseudosolubility of hydrophobic compounds. It also exhibits antibacterial activity against Escherichia coli, Vibrio harveyi, Proteus vulgaris, and Candida albicans. The mode of biocidal action is by antiadhesion. It also has hydration and restructuring properties. graphic file with name pharmaceutics-13-01024-i003.jpg 37 mg/L [144]
Sophorolipid Glycolipid Fungi Rhodotorula bogoriensis This biosurfactant has antiaging properties, specifically antiwrinkling. graphic file with name pharmaceutics-13-01024-i004.jpg 9.5 mg/L [145]
Cellobioselipid Glycolipid Fungi Pseudozymafusiformata, Cryptococcus humicola, Sclerotinia sclerotiorum, Phomopsis helianthi, Ustilago maydis This biosurfactant can facilitate the dissolution and consumption of organic hydrophobic compounds. It is also known for its antifungal properties. graphic file with name pharmaceutics-13-01024-i005.jpg 2 × 10−5 M (pH 4.0), 3.3 × 10−5 M (pH 4.0) [146]
Emulsan Polymeric biosurfactant Bacteria Acinetobacter calcoaceticus This biosurfactant is used in the removal of residual oil in oil tanks. graphic file with name pharmaceutics-13-01024-i006.jpg no information available [147]
Surfactin Lipopeptides and oligopeptides Bacteria Bacillus subtilis This biosurfactant inhibits fibrin clot formation and has antibacterial properties. graphic file with name pharmaceutics-13-01024-i007.jpg 9.4 µM (pH 8.7) [148,149]
Viscosin Lipopeptides and oligopeptides Bacteria Pseudomonas sp. This biosurfactant has antifungal activity against Aspergillus fumigatus and Batrachochytrium dendrobatidis. graphic file with name pharmaceutics-13-01024-i008.jpg 54 mg/L [150,151]
Amphisin Lipopeptides and oligopeptides Bacteria Pseudomonas sp. This biosurfactant has antifungal activity. graphic file with name pharmaceutics-13-01024-i009.jpg 54 mg/L [152]
Tolaasin Lipopeptides and oligopeptides Bacteria Pseudomonas This biosurfactant has antibacterial activity against Bacillus megaterium. graphic file with name pharmaceutics-13-01024-i010.jpg no information available [153]
Syringomycin Lipopeptides and oligopeptides Bacteria Pseudomonas sp. This biosurfactant has fungicidal activity against various yeast, Aspergillus species, Candida, Cryptococcus, and Geotrichum. graphic file with name pharmaceutics-13-01024-i011.jpg 1.25 mg/mL [154]
Serrawettin Lipopeptides and oligopeptides Bacteria Serratia marcescens This biosurfactant has slight or almost insignificant antibacterial activity. graphic file with name pharmaceutics-13-01024-i012.jpg no information available [155]