Table 1.

Formulation variables range used to optimize BF-loaded NLCs.

Parameters	Constraints
	Lower Value	Medium Value	Upper Value
Independent variables
Lipid concentration (A, %)	2	3	4
Surfactant concentration (B, %)	1	2	3
Homogenization cycle (C, n)	2	4	6
Dependent variables	Goals
Particle size (Y1, nm)	Minimize
Entrapment efficiency (Y2, %)	Maximize