Table 5.

Current FDA approved skin healing products from native collagen.

Formulations	Product	Pharmaceutical Company	Indication	Contraindication	Benefits
Bovine derived Col type I	HyCol Collagen Powder	Sanara Med Tech Inc.	Chronic and acute wounds, partial and full-thickness wounds, all types of pressure injuries, venous stasis ulcers, arterial ulcers, diabetic ulcers, traumatic wounds, and 1st degree burns	Not recommended for those allergic to bovine derivative products.	Effective, versatile, easy to apply and compatible.
Bovine derived Col type I	Stimulen Collagen Powder	Southwest Technologies Inc.	Partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, partial-thickness burns, acute wounds, abrasions, and traumatic wounds	Not recommended for those allergic to bovine derivative products.	One time application, prevents dehydration, ease of usage, provide moist microenvironment, non-cytotoxic nonirritating, exudates break down the Col powder.
Native equine type I Collagen	Biopad	L&R USA, Inc.	Pressure ulcers, venous insufficiency ulcers, diabetic ulcers, partial- and full-thickness wounds, surgical and traumatic wounds, draining wounds, lacerations, podiatric, and post-laser surgery	-	Rapidly heals hard to heal wounds.
Porcine derived Col type I	Biostep Collagen Matrix	Smith and Nephew, Inc.	Full and partial-thickness wound, pressure ulcers, diabetic ulcers, venous ulcers, abrasions, traumatic wounds, dehisced surgical wounds and 1st and 2nd degree burns	Not recommended for those allergic to porcine derivative products and 3rd degree burns.	Targets MMPs and optimizes moisture surface at the injury site. Ease of application.
Bovine derived Col type I	Collatek Collagen Gel	Human BioSciences, Inc	Abrasions, cuts, superficial injuries, severe sunburns, partial and full thickness wounds, venous stasis ulcers, 1st and 2nd degree burns, ulcers	Not recommended for those allergic to bovine derivative products.	Prevents dehydration, optimizes moisture microenvironment, fills cavity wounds, ease of application and cost effective.
Native Col	Cutimed Epiona	Essity	Full thickness skin loss	-	3D matrix that enhances skin regeneration, decreases enzymatic degradation, provides structural support, and enhances cell proliferation by creating ECM like structure.
Bovine derived Col type I	DermaCol 100	DermaRite Industries, LLC	Full and partial-thickness wounds, pressure ulcers, diabetic ulcers, venous ulcers, abrasions, traumatic wounds, dehisced surgical wounds and 1st and 2nd degree burns	Not recommended for those allergic to bovine derivative products and 3rd degree burns.	High absorbent capacity, optimize moist surface at the wound site, and aids hemostatic process.
Bovine derived Col type I	DermaCol 100 Sheet	DermaRite Industries, LLC	Moderately to heavily exuding wounds with minor bleeding	Not recommended for those allergic to bovine derivative products.	Optimizes moist surface at the wound site, absorb exudates, and aids hemostatic process.
Bovine derived Col	Gentell Collagen	Gentell	Burns, sores, blisters, scrapes and ulcers.	Not recommended for those allergic to bovine derivative products.	Regulates MMPs, aids in hard to heal wounds, and can be used at any stage of wound healing.
Bovine derived Col type I	Helix 3 Bioactive Collagen	Amerx Health Care Corp.	Burns, sores, blisters, ulcers, and exuding wounds	Not recommended for those allergic to bovine derivative products.	Optimizes moist surface at the wound site, absorbs exudates, effective in all wound healing phases, and available in many forms such as gels, powders, etc.
Bovine derived Col	Medifill II Collagen Particles	Human BioSciences, Inc.	Burns, sores, blisters, scrapes, and ulcers.	Not recommended for those allergic to bovine derivative products.	Absorbing capacity, on shelf biomaterial, optimizes moist microenvironment, allows gas exchange, and cost effective.
Bovine derived Col type I	PuraCol Plus MicroScaffold Collagen	Medline Industries, Inc.	Partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, donor sites and other bleeding surface wounds, abrasions, trauma wounds, and 1st and 2nd degree burns.	Not recommended for those allergic to bovine derivative products.	Aids in chronic wounds, exudate absorbing capacity, optimizes moist microenvironment, and aids cell growth.
Bovine derived Col type I	PuraCol Ultra Powder	Medline Industries, Inc.	Partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, donor sites and other bleeding surface wounds, abrasions, trauma wounds, and 1st and 2nd degree burns.	Not recommended for those allergic to bovine derivative products.	Bioabsorbent, optimizes moist microenvironment, and aids in regeneration of granulation tissue.
Undigested bovine derived Col	Simpurity Collagen Pad	Safe n’ Simple	Partial and full-thickness wounds, tunnel or undermined wounds or surgical wounds, low to moderately exuding chronic wounds including diabetic foot ulcers, venous leg ulcers and sores	Not recommended for those allergic to bovine derivative products.	High exudate absorption, retention provides moist wound healing environment, acts as hemostatic agent, and ease of application.
Bovine derived Col	SkinTemp II Collagen Sheets	Human BioSciences, Inc.	Burns, sores, blisters, scrapes and ulcers	Not recommended for those allergic to bovine derivative products.	Sustained adherence, hypoallergenic, non-pyrogenic, non-toxic, fluid control, impermeable to exogenous microorganisms, absorbs exudates, on shelf biomaterial, ease of application, and cost effective.
Animal derived Col	Stimulen Collagen Gel	Southwest Technologies, Inc.	Partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, donor sites and other bleeding surface wounds, abrasions, trauma wounds, and 1st and 2nd degree burns.	Not recommended for those allergic to animal derivative products.	Prevents dehydration, optimizes moist microenvironment, fills cavity wounds, nontoxic, and nonirritating.
Type I Col	Triple Helix Collagen Dressing	MPM Medical, Inc.	1st and 2nd degree burns, full and partial-thickness wounds, pressure ulcer stages II-IV, diabetic vascular and venous insufficiency ulcers, and light to heavily exudating wounds.	-	Can be customized to any desired size.