Table 2.
Diagnosis and Treatment History Results
| Characteristic | Current Episode (n=71) | Previous Episode (n=4) | |
|---|---|---|---|
| Time since first diagnosed with depression – n (%) | In the last 6 months | 1 (1.4) | 0 |
| In the last 6–12 months | 2 (2.8) | 0 | |
| 1–2 years ago | 5 (7.0) | 1 (25) | |
| 2–5 years ago | 11 (15.5) | 1 (25) | |
| More than 5 years ago | 51 (71.8) | 2 (50) | |
| Do not know | 1 (1.4) | 0 | |
| Diagnosed with anxiety disorders during depressive episode – n (%) | Yes | 50 (70.4) | 3 (75) |
| No | 21 (29.6) | 1 (25) | |
| Length of depressive episode – n (%) | 3–6 months | 16 (22.5) | 2 (50) |
| 6–12 months | 11 (15.5) | 0 | |
| 12–24 months | 8 (11.3) | 2 (50) | |
| More than 24 months | 36 (50.7) | 0 | |
| Treatments tried during depressive episode – na | Antidepressants and medications prescribed for antidepressant effect | 69 | 4 |
| Other prescription medications | 20 | 2 | |
| Psychological therapy | 42 | 3 | |
| Mindfulness | 39 | 0 | |
| Electroconvulsive therapy (ECT) | 7 | 0 | |
| Transcranial magnetic stimulation (TMS) | 6 | 0 | |
| Lifestyle changes | 44 | 0 | |
| Ketamine/esketamine | 1 | 0 | |
| Other | 3 | 0 | |
| Medications tried for at least 6 weeks during depressive episode – na | SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine) | 133 | 5 |
| Atypical antipsychotics (aripiprazole, olanzapine, quetiapine) | 36 | 2 | |
| Tricyclic antidepressants (amitriptyline, clomipramine, dothiepin, doxepin, nortriptyline, trimipramine) | 35 | 1 | |
| SNRIs (duloxetine, desvenlafaxine) | 29 | 2 | |
| Tetracyclic antidepressants (mirtazapine, mianserin) | 19 | 1 | |
| Serotonin receptor activity modulators (vortioxetine) | 8 | 0 | |
| MAOIs (phenelzine, tranylcypromine) | 7 | 0 | |
| Noradrenaline reuptake inhibitors (reboxetine) | 7 | 0 | |
| RIMAs (moclobemide) | 7 | 0 | |
| Melatonergic antidepressants (agomelatine) | 5 | 0 | |
| Selective catecholamine reuptake inhibitors (bupropion) | 1 | 0 |
Note: aParticipants may have tried more than one treatment.
Abbreviations: SSRIs, selective serotonin reuptake inhibitors; SNRIs, serotonin noradrenaline reuptake inhibitors; MAOIs, monoamine oxidase inhibitors; RIMAs, reversible inhibitors of monoamine oxidase A.