Figure 3.

The two main avenues to assess the inhibitory potential of plant extracts and other natural products against the action of snake venoms. Extracts can be tested for their inhibitory action in preclinical models. Extracts that yield positive results can be fractionated and the secondary metabolites responsible for inhibition are characterized and used as lead compounds for further pharmaceutical development. On the other hand, plant extracts can be tested in experimental animal models, on the basis of ethnopharmacological knowledge, by following the way extracts are prepared and administered according to popular traditions. The plant Aristolochia grandiflora is a source of molecules with inhibitory potential against various snake venom toxins. Created with BioRender.com.