Table 3.
Association of gMB species with uremic toxins, oxidative stress and inflammatory cytokines.
| SPECIES | Uremic Toxins | Anti-Inflammatory Cytokines |
Pro-Inflammatory Cytokines |
Oxidative Stress | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IS µmol/L |
PCs µmol/L |
IL-10 pg/mL |
IL-12 pg/mL |
Fetuin-A ng/mL |
IL-6 pg/mL |
IL-17 pg/mL |
TNF-α pg/mL |
MCP-1 pg/mL |
MDA µmol/L |
||
| Lactobacillus Unclass.Lactobacillus | r p |
0.42
0.0005 |
−0.04 0.76 |
0.21 0.10 |
0.098 0.45 |
0.2 0.12 |
−0.11 0.39 |
−0.02 0.88 |
−0.3
0.016 |
0.09 0.48 |
−0.042 0.74 |
| Bifidobacterium-longum | r p |
0.25
0.047 |
0.012 0.93 |
0.11 0.39 |
−0.19 0.15 |
0.16 0.21 |
−0.12 0.35 |
0.0056 0.97 |
0.11 0.40 |
−0.12 0.35 |
0.092 0.47 |
| Eubacterium-biforme | r p |
0.061 0.64 |
0.35
0.006 |
0.12 0.33 |
−0.043 0.74 |
0.13 0.32 |
−0.016 0.89 |
−0.24 0.06 |
−0.019 0.88 |
0.11 0.39 |
−0.089 0.49 |
| Oscillospira | r p |
0.18 0.16 |
0.28
0.029 |
0.083 0.51 |
−0.096 0.46 |
0.017 0.90 |
0.079 0.54 |
−0.034 0.80 |
0.087 0.49 |
−0.14 0.28 |
0.045 0.72 |
|
Bacteroides-Unclass.
Bacteroides |
r p |
0.056 0.66 |
−0.1 0.43 |
−0.26
0.04 |
−0.019 0.88 |
0.00004 0.99 |
0.29
0.02 |
−0.15 0.26 |
0.28
0.026 |
−0.26
0.042 |
0.093 0.47 |
| Collinsella-aerofaciens | r p |
0.12 0.37 |
0.092 0.48 |
0.15 0.23 |
0.01 0.94 |
0.28
0.02 |
−0.12 0.36 |
0.28
0.028 |
−0.14 0.27 |
0.07 0.58 |
0.052 0.69 |
| Clostridium-difficile | r p |
0.13 0.30 |
0.059 0.65 |
0.14 0.27 |
−0.095 0.46 |
0.2 0.12 |
−0.024 0.85 |
−0.099 0.45 |
−0.058 0.65 |
0.054 0.67 |
−0.16 0.22 |
| Unclass. Christensenellaceae | r p |
0.074 0.57 |
0.29 0.021 |
−0.15 0.24 |
0.034 0.79 |
0.037 0.77 |
0.03 0.82 |
−0.2 0.13 |
−0.001 0.99 |
−0.064 0.61 |
−0.052 0.68 |
| Unclass. Clostridiaceae | r p |
0.21 0.098 |
0.34
0.007 |
−0.01 0.94 |
−0.04 0.76 |
0.15 0.22 |
0.064 0.62 |
−0.22 0.096 |
0.045 0.73 |
−0.018 0.88 |
−0.09 0.46 |
| Unclass. Mogibacteriaceae | rp | 0.1 0.44 |
0.29
0.023 |
0.15 0.22 |
−0.16 0.21 |
0.054 0.67 |
−0.072 0.57 |
−0.11 0.40 |
0.023 0.86 |
−0.038 0.76 |
0.063 0.62 |
PCs, p-cresyl sulfate; IS, indoxyl sulfate; IL, interleukin; TNF-α, tumor necrosis factor alpha; MCP-1, monocyte chemoattractant protein-1; MDA, malondialdehyde. Significant correlations are highlighted in bold.