Figure 1.

Antiviral effect of resveratrol and pterostilbene towards SARS-CoV-2 in Vero E6 cells. Production of infectious virus particles by Vero E6 cells inoculated with SARS-CoV-2 at MOI 1 in the absence (NT denotes for non-treated) or presence of increasing concentrations of (A) resveratrol, (B) pterostilbene or (A,B) the EtOH solvent control. (C) The EC50 and EC90 values determined by nonlinear regression analysis. (D,E) Durability of the antiviral effect of (D) resveratrol 150 µM and (E) pterostilbene 60 µM at 16, 24, 40, and 60 hpi. Dotted line indicates the threshold of detection. Data are represented as mean ± SEM of at least three independent experiments. Each symbol represents data from a single independent experiment. Student T test was used to evaluate statistical differences and a p value ≤ 0.05 was considered significant with * p ≤ 0.05, ** p ≤ 0.01 and *** p ≤ 0.001. In the absence of ‘*’ the data are non-significant.