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. 2021 Jul 12;9(7):774. doi: 10.3390/vaccines9070774

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Neutralization by mAbs and Ig-Adhesins. Neutralization was studied using the TZM-bl assay with 44 different tier 1 and 2 pseudotyped HIV isolates (A). The panel of mAbs and Ig-adhesins, along with a mixture of CH01+CH31 neutralizing mAbs was tested for potency and breadth of neutralization. Vertical axis is percentage of isolates neutralized, the horizontal is IC₅₀ (µg/mL) (B). Comparison of experimental results with historical data in CATNAP. The upper left panel compares mAb 8ANC195 experimental vs historical data. The remainder compare two Ig-Adhesins to other potent, broadly-neutralizing mAbs. Axes are the same.