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. 2021 Jul 19;9(7):800. doi: 10.3390/vaccines9070800

Figure 3.

Figure 3

Safety and immunogenicity of the B/Bris PB1att 4M virus. DBA/2J 4-week-old, male and female mice were inoculated I.N. with either B/Bris PB1att 4M or PBS (mock group). (A) Percentage body weight change was evaluated daily for 12 days following vaccination. (B) Immunogenicity of the B/Bris PB1att 4M virus was measured by HI assay in mouse sera at 20 days post-boost (dpb). Shaded area indicates cutoff for HI titers considered to be predictive of protection. Weight loss data were compared using two-way ANOVA corrected for multiple comparisons using Holm–Sidak’s test. Significant differences, compared with mock group, are indicated. ** p < 0.01. Plotted data represent means ± standard errors.