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. 2021 Jul 12;13(7):1349. doi: 10.3390/v13071349

Figure 1.

Figure 1

Rotavirus structure, replication cycle. (A,B) Schematic representation of triple-layered and double-layered rotavirus particles (TLPs and DLPs, respectively). Outer layer: VP7, VP4 (spikes); middle layer: VP6; inner layer (core): VP2. The core contains 11 segments of dsRNA (diagrammatically shown as concentric rings) and the viral transcription–replication complex, consisting of the RNA-dependent RNA polymerase (RdRp), VP1, and the capping enzyme, VP3. Rotavirus DLPs are transcription active, producing (+)ssRNAs from each genomic RNA segment. Adapted from: ViralZone, SIB Swiss Institute of Bioinformatics; (C) Rotavirus replication cycle (diagram) including formation of viroplasms. For details, see text. Adapted from: ViralZone, SIB Swiss Institute of Bioinformatics.