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. 2021 Jun 25;9(7):698. doi: 10.3390/vaccines9070698

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Serum antibody responses across conserved influenza epitopes in mice immunized with unconjugated or CRM-conjugated composite peptide (HA, NA and M2e) vaccine at 0.5, 1 and 2.5 µg/mouse, and formulated with ALFQ. Day 0, 21 and 42 sera samples were analyzed by ELISA. Panels (A,B), IgG1 titers (1:100 dilution) on individual peptides HA (Flu Pep3) and NA (Flu Pep10), and Panels (C,D), on composite peptides HA+NA (Flu Pep11) and M2e (Flu Pep5906), respectively. No significant differences were observed between the two groups as determined by ANOVA. Data are expressed as mean ± standard deviation (SD).