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. 2021 Jun 25;9(7):698. doi: 10.3390/vaccines9070698

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Profile of serum IgG1 responses across composite HA+NA and M2e peptides in mice immunized with 1 µg of composite influenza peptide (HA, NA and M2e) vaccine, unconjugated or CRM-conjugated, and formulated with ALFQ. Day 0, 21, 35, and 42 sera samples were analyzed by ELISA. Panel (A), IgG1 titers (1:100 dilution) on Flu Pep11 (HA+NA). Panel (B), on Flu Pep5906 (M2e). Data are expressed as mean ± SEM. Overall, the antibody responses on day 21 were significantly higher (ANOVA, p = 0.0421) for unconjugated peptides compared to CRM-conjugated peptides.