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Mechanism of anti-PD-1/PD-L1 and anti-CTLA-4 ICIs in anti-cancer therapy for NSCLC. Abbreviations: APC, antigen-presenting cell; TCR, T-cell receptor; MHC, major histocompatibility complex; PD-L1, programmed Death-Ligand 1; PD-1, programmed Cell Death Protein-1 (PD-1); CTLA-4, cytotoxic T-lymphocyte-associated protein 4.
