Table 4.
IC50 (half-maximal inhibitory concentration) values of CR9114 and FI6 against representative influenza PV in vitro. (-) indicates no neutralization. n.d. indicates the experiment was not done.
| Pseudotype Virus (PV) | IC50 (ng/mL) | ||
|---|---|---|---|
| Subtype | Strain | CR9114 | FI6 |
| H1 | A/England/195/2009 | 3.63 | 13.25 |
| H2 | A/quail/Rhode Island/16-018622-1/2016 | 5.06 | 26.70 |
| H3 | A/ruddy turnstone/Delaware Bay/606/2017 | 51.62 | 9.83 |
| H4 | A/Calidris ruficollis/Hokkaido/12EY0172/2012 | 1.68 | 8.36 |
| H5 | A/gyrfalcon/Washington/41088-6/2014 | 10.74 | 60.15 |
| H6 | A/American wigeon/California/HS007A/2015 | 0.68 | 2.91 |
| H7 | A/Shanghai/02/2013 | 11.88 | 17.39 |
| H8 | A/mallard duck/Ohio/16OS0672/2016 | 0.71 | 0.23 |
| H9 | A/chicken/Israel/291417/2017 | 0.39 | 6.41 |
| H10 | A/mallard/Utah/D1802334/2018 | 1.26 | 0.57 |
| H11 | A/red shoveler/Chile/C14653/2016 | 120.90 | 0.02 |
| H12 | A/duck/Mongolia/850/2018 | 15.06 | 0.51 |
| H13 | A/laughing gull/New Jersey/UGAI17-2843/2017 | 31.97 | 52.05 |
| H14 | A/blue-winged Teal/Ohio/18OS1695/2018 | 0.58 | 0.06 |
| H15 | A/wedge-tailed shearwater/Western Australia/2576/1979 | 10.73 | 14.12 |
| H16 | A/black-headed gull/Netherlands/1/2016 | 45.41 | 55.50 |
| H17 | A/little yellow-shouldered bat/Guatemala/60/2010 | 0.54 | 0.34 |
| H18 | A/flat-faced bat/Peru/033/2010 | 0.26 | 3.14 |
| B | B/Hong Kong/8/1973 | - | n.d. |
| B/Vic | B/Victoria/1/1987 | - | n.d. |
| B/Yam | B/Yamagata/16/1988 | - | n.d. |