Table 2.
Clinical sensitivity according to the time post symptom onset.
| Overall Sensitivity N, % (95% CI) |
D 0–5 N, % (95% CI) |
D 6–10 % (95% CI) |
D 11–15 % (95% CI) |
D 16–20 % (95% CI) |
D 21–30 % (95% CI) |
D 31–90 % (95% CI) |
D ≥ 91 % (95% CI) |
Specificity % (95% CI) |
|
|---|---|---|---|---|---|---|---|---|---|
| Sample No. | 528 | 56 | 89 | 90 | 77 | 62 | 114 | 40 | 161 |
| CMIA (Abbott) | |||||||||
| IgM antiS | 394 74.6 (70.6–78.2) |
13 23.2 (12.9–36.4) |
54 60.6 (49.7–70.8) |
83 92.2 (84.6–96.8) |
74 96.1 (89–99.1) |
57 91.9 (82.1–97.3) |
89 78 (69.3–85.2) |
24 60 (43.3–75.1) |
2 98,7 (95.5–99.8) |
| IgG antiNP | 372 70.4 (66.3–74.3) |
8 14.2 (6.3–26.2) |
27 30.3 (21–40.9) |
72 80 (70.2–87.6) |
72 93.5 (85.4–97.8) |
57 91.9 (82,1–97.3) |
103 90.3 (83.3–95) |
33 82.5 (67.2–92.6) |
2 98,7 (95.5–99.8) |
| IgM/IgG * | 437 82.7 (79.2–85.8) |
13 23.2 (12.9–36.4) |
56 62.9 (52–72.9) |
86 95.5 (89–98.7) |
75 97.4 (90.9–99.6) |
60 96.7 (88.8–99.6) |
111 97.3 (92.5–99.4) |
36 90 (76.3–97.2) |
4 97.5 (93.7–99.3) |
| ELISA (Epitope) | |||||||||
| IgM antiNP | 149 28.2 (24.4–32.2) |
6 10.7 (4–21.8) |
21 23.5 (15.2–33.7) |
51 56.6 (45.8–67) |
31 40.2 (29.2–52) |
25 40.3 (28.5–53.5) |
13 11.4 (6.21–18.87) |
2 5 (0.6–16.9) |
4 97.5 (93.7–99.3) |
| IgG antiNP | 343 64.9 (60.7–69) |
10 17.8 (8.9–30.4) |
31 34.8 (25–45.6) |
68 75.5 (65.3–84) |
65 81.8 (71.3–89.6) |
54 85.4 (74.2–93.1) |
90 78 (69.3–85.2) |
25 60 (43.3–75.1) |
3 98.1 (94.6–99.6) |
| IgM/IgG * | 359 68 (63.8–72) |
10 17.9 (8.9–30.4) |
33 37.1 (27.1–48) |
73 81.1 (71.5–88.6) |
66 85.7 (75.9–93) |
58 93.5 (84.3–98.2) |
92 80.7 (72.2–87.5) |
27 67.5 (50.9–81.4) |
5 96.2 (92–98.6) |
| Sample No. | 559 | 56 | 89 | 90 | 77 | 62 | 114 | 71 | 161 |
| CLIA IgG antiS1/S2 DiaSorin | 390 69.8 (65.7–73.5) |
6 10.7 (4–21.8) |
22 24.7 (16.1–35) |
64 71.1 (60.6–80.1) |
68 88.3 (78.9–94.5) |
54 87 (76.1–94.2) |
107 93.8 (87.7–97.5) |
69 97.2 (83–99.3) |
2 98.7 (95.5–99.8) |
| Sample No. | 559 | 56 | 89 | 90 | 77 | 62 | 114 | 71 | 158 |
| ECLIA total antiNP Roche | 403 70.4 (66.3–74.3) |
7 12.5 (5.1–24) |
29 32.5 (23–43.3) |
64 71.1 (60.6–80.1) |
68 88.3 (78.9–94.5) |
54 87 (76.1–94.2) |
110 96.4 (91.2–99) |
71 100 (91.1–100) |
0 100 (97.7–100) |
* Positive if either IgM or IgG is positive.