Table 1.
Approaches for vaccines against N. gonorrhoeae.
| Vaccine Approach | Vaccine Components/Antigens under Investigation 1 | References |
|---|---|---|
| Meningococcal and gonococcal OMVvaccines | VA-MENGOC-BC® | [141] |
| MeNZB®: NZ 98/254 OMV (Omp85, FetA, PorA, PorB3, FbpA, RmpM, OpcA, and NspA) Formalin-inactivated whole cell microparticles |
[142,143] | |
| Purified protein subunit vaccines |
AniA, Lst, OmpA, Opa, OpcA, PilC, PilQ, PorB, TbpB, TbpA, TdfJ, NgoΦfil phage particles | [135,144] |
| Mixed OMV and protein subunit vaccines |
Bexsero®: MeNZB OMV antigens with additional fHbp, NHBA, and NadA antigens | [145] |
| Immunotherapeutic vaccines |
OMV vaccine with IL-12 adjuvant | [130] |
| 2C7 LOS epitope mimic multi-antigenic peptide vaccine | [132] |
1 Omp85, outer membrane protein assembly factor; FetA, ferric enterobactin receptor; PorA and PorB, outer membrane porin protein; FbpA, fibronectin binding protein; RmpM, reduction-modifiable protein; OpcA, outer membrane adhesin; NspA, neisserial surface protein; AniA, anaerobically induced copper-containing nitrite reductase; Lst, lipooligosaccharide-specific α-2,3-sialyltransferase; OmpA, outer membrane protein; PilC, Type IV pilus assembly protein; PilQ, Type IV pilus biogenesis and competence protein; TbpA and TbpB, transferrin-binding protein; TdfJ, outer membrane TonB-dependent transporter protein; fHbp, factor H binding protein; NHBA, neisserial heparin binding antigen; and NadA, Neisseria adhesin and invasin.