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. 2021 Jun 25;9(7):700. doi: 10.3390/vaccines9070700

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of the results of the surrogate neutralization tests (sVNT) #1 (a) and #2 (b) with those of the cell-based neutralization test (cVNT) using a ‘wildtype’ SARS-CoV-2 strain (wt) and a B.1.1.7 strain as antigens. A serum dilution of >1:10 is considered as protective. The decision limits for relevant inhibition of SARS-CoV-2 receptor-binding domain interaction with the human angiotensin-converting enzyme 2 varies between ≥20% (sVNT#2) and ≥30% (sVNT#1). Spearman correlation coefficients were calculated with 0.85 (sVNT#1 vs. cVNT with wt), 0.80 (sVNT#1 vs. cVNT with B.1.1.7), 0.92 (sVNT#2 vs. cVNT with wt), and 0.85 (sVNT#2 vs. cVNT with B.1.1.7), respectively.