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. 2021 Jul 6;9(7):750. doi: 10.3390/vaccines9070750

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Stabilized ConC trimers show favorable binding profiles to bnAbs and non-nAbs. ELISA binding curves for selected broadly neutralizing (bnAb) and non-neutralizing (non-nAb) antibodies. Teal: ConC KIKO gp120; orange: ConCv1 KIKO NFL; lilac: ConCv2 KIKO; pink: ConCv4 KIKO; green: ConCv5 KIKO. PGT145 (trimer specific); PGT151 (gp120/gp41-interface and fusion peptide targeting); PG9 and PG16 (V2 apex targeting and quaternary structure dependent); PGT121 and 10-1074 (V3 supersite); VRC01 (CD4bs); F105 (malfolded CD4bs); 19b, 14E, and 447-52D (V3 loop); and 17b (co-receptor binding site, CD4 induced state), 5F3 (MPER), and 2G12 (glycan-dependent). Curves are shown for one representative of two experiments. Mean EC50 values ± SEM are given. n.b.d.: no binding detected; w.b.: weak binding.