Table 2.
Various enveloped viruses and the sequences of surrounding their surface glycoprotein cleavage sites (designated by an arrow) by Furin(-like) proprotein convertases. The bold and underlined residues at positions P8, P6, P4, P2, P1 and P2′ emphasize the importance of these amino acids for protease recognition.
| Virus | Glycoprotein | P8 | P6 | P4 | P2 | ↓ | P2′ | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HIV | gp160 | V | Q | R | E | K | R | A | V | ||
| H7N1 A/FPV/Rostock/34 | HA | K | K | R | E | K | R | G | L | ||
| Avian H5N8 TKY/IRE | HA | R | K | R | K | K | R | G | L | ||
| Avian H5N1 A/HK/97 | HA | R | E | R | R | R | K | K | R | G | L |
| Avian H5N1 TKY/ENG | HA | N | T | P | Q | R | K | K | R | G | L |
| Human CMV | gB | H | N | R | T | K | R | S | T | ||
| Human MPV | F Protein | N | P | R | Q | S | R | F | V | ||
| Human RSV | F Protein | K | K | R | K | R | R | F | L | ||
| Dengue Virus (DENG2) | PrM | H | R | R | E | K | R | S | V | ||
| Ebola Virus | gp160 | G | R | R | T | R | R | E | A | ||
| Chikungunya (CHIKV) | E3E2 | P | R | R | Q | R | R | S | I | ||
| Zika Virus | PrM | A | R | R | S | R | R | A | V | ||
| SARS-CoV-2 | S | S | P | R | R | A | R | S | V | ||