Figure 7.

The structure of defensins required for anti-SARS-CoV-2 activity. To determine the effect of linear defensins (A) or proHD5 (B) on viral infection, pseudotyped SARS-CoV-2 virus was incubated with indicated concentrations of [Abu]HNP1 or [Abu]HD5 for 1 h before infection of HEK293T-hACE2 cells. Infected cells were cultured for three days before measuring luciferase activity. There was no difference between defensin-treated samples and untreated controls as calculated by Student’s two-tailed t-test. Data are means ± SD of triplicate samples and are representative of two independent experiments.