Table 3.

Unadjusted pair analyses for all biomarkers. BMI: body mass index; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol; GGT: gamma-glutamyl transferase; and INR: international normalized ratio.

Biomarker	Pairs
	T0–T1 (Both Pre-DAA Treatment)							T1–T2 (Pre- and Post-DAA Treatment)
	N	Mean1	SD1	Mean2	SD2	Δ	p-Value	N	Mean1	SD1	Mean2	SD2	Δ	p-Value
BMI, kg/m2	139	26.5	27.2	25	21	−1.4	0.33	237	26.1	23.3	28.4	32	2.3	0.19
Blood glucose, mg/dL	551	96.21	30.04	94.88	26.43	−1.32	0.23	868	95.46	26.68	95.31	26.97	−0.16	0.82
Creatinine, mg/dL	658	0.7	0.5	0.8	4	0.1	0.39	1027	0.8	3.2	0.7	0.7	−0.1	0.39
Total cholesterol, mg/dL	432	162.6	43.1	161.5	42.2	−1.2	0.37	617	162	40.7	183.5	41	21.4	<0.01
LDL cholesterol, mg/dL	170	96.6	38.8	94.6	37.7	−2	0.27	235	91.9	34.3	114.4	32.2	22.4	<0.01
HDL cholesterol, mg/dL	249	44.1	14.9	44.1	14.4	0	0.98	360	46	16.8	46.5	14.3	0.5	0.45
Triglycerides, mg/dL	431	137.2	83	134.6	78.1	−2.6	0.45	617	132.7	75.5	134.9	81.1	2.2	0.49
ALT, mg/dL	667	83.79	78.14	78.24	62.42	−5.56	0.02	1047	79.57	64.04	25.58	18.95	−54	<0.01
AST, mg/dL	614	66.49	49.84	64.08	42.65	−2.41	0.13	989	66.2	46.87	27.31	15.64	−38.9	<0.01
GGT, mg/dL	417	126.6	169.7	109.3	112.2	−17.3	<0.01	650	107.9	116.2	47.01	90.8	−60.9	<0.01
Total bilirubin, mg/dL	641	0.68	0.92	0.66	1.04	−0.03	0.49	987	0.67	1.01	0.56	0.8	−0.11	<0.01
Platelets/mmc	670	173.8	77.7	170.4	70.9	−3.4	0.02	1055	308.3	4552	180	72.9	−128	0.36
INR	98	0.95	0.35	0.98	0.34	0.03	0.55	188	0.95	0.38	1	0.37	0.05	0.18
CD4 count, cells/mmc	731	689.2	706.7	860.6	3807	171.4	0.22	1065	811.8	3206	748.2	824.7	−63.7	0.52
CD8 count, cells/mmc	669	923.9	498.8	926	546.3	2.14	0.87	924	916.5	565.4	957.5	577	40.97	0.01
CD4/CD8 ratio	669	0.79	0.43	0.94	3.02	0.15	0.21	924	1.13	5.21	2.46	48.43	1.33	0.41
HIV RNA log10 cp/mL	658	0.92	1.08	0.78	0.9	−0.15	<0.01	978	0.77	0.89	0.68	0.9	−0.1	<0.01