Table 2.

Cutaneous hypersensitivity and host grooming response to reduce tick infestation.

Cutaneous Hypersensitivity Induced Grooming Response Observations	Publication	Reference Number
Bovine acquired resistance cutaneous hypersensitivity associated with exudate that traps ticks, bite site vesicles, poorly fed and dead ticks	Bishopp and Wood, 1913; Johnston and Bancroft, 1918; Riek, 1962	[42] [43] [44]
Increased histamine levels; Mast cell degranulation at bite sites on resistant cattle; Basophil influx with ticks trapped in serous exudate	Riek, 1962 Schleger et al., 1976 Allen et al., 1977	[44] [58] [59]
Grooming in response to tick induced pruritus is an important factor in expression of acquired resistance	Snowball, 1956 Bennett, 1969 de Castro and Newson, 1993 Hart, 2000	[65] [67] [66] [69]
Human hypersensitivity to tick bite correlates with reduced incidence of tick-borne infections	Burke et al., 2005	[70]