Table 1.

Native AAV structures.

Serotype	Clade	Resolution	Year	Tropism 1	Tropism 2	Tropism 3	Reference	PDBid
AAV1	A	X-ray 2.5 Å	2010	Muscle, CNS, heart	Skin, lung, kidney, cervix, bone	Kidney, skin	Ng et al. [21]	3NG9
AAV2	B	X-ray 3.0 Å	2002	Liver, CNS, muscle	Skin, lung, kidney, cervix, liver, bone	Liver, kidney, cervix, retina, skin	Xie et al. [22]	1LP3
AAV3	C	X-ray 2.6 Å	2010	Muscle, stem cells	Skin, lung, kidney, cervix, liver, bone	Skin	Lerch et al. [23]	3KIC
AAV4	Unique	X-ray 3.2 Å	2006	Eye, CNS	Bone	Not detected	Govindasamy et al. [24]	2G8G
AAV5	Unique	X-ray 3.5 Å	2013	CNS, lung, eye	Not detected	Not detected	Govindasamy et al. [25]	3NTT
AAV6	A	X-ray 3.0 Å	2011	Muscle, CNS, heart, lung	Skin, lung, kidney, cervix, bone	Skin	Xie et al. [26]	4V86
AAV7	D	Cryo-EM 3.0 Å	2021	Muscle, CNS	Not detected	Not detected	Mietzsch et al. [20]	7L5Q
AAV8	E	X-ray 2.6 Å	2007	Liver, muscle, pancreas, CNS	Not detected	Not detected	Nam et al. [27]	2QA0
AAV9	F	X-ray 2.8 Å	2012	Broad distribution	Not detected	Not detected	Dimattia et al. [28]	3UX1
AAVrh.39 (AAV10-like)		Cryo-EM 3.4 Å	2020	Muscle (AAV10)	Not tested	Not tested	Mietzsch et al. [29]	6V1T
AAV11		Cryo-EM 2.9 Å	2021	Unknown	Not tested	Not tested	Mietzsch et al. [20]	7L6F
AAV12		Cryo-EM 2.5 Å	2021	Nasal	Not tested	Not tested	Mietzsch et al. [20]	7L6B
AAV13		Cryo-EM 3.0 Å	2021	Not shown	Not tested	Not tested	Mietzsch et al. [20]	7L6I
AAVDJ		Cryo-EM 4.5 Å	2012	Not shown	Not tested	Liver, kidney, cervix, retina, skin, lung	Lerch et al. [30]	3J1Q
AAVDJ		Cryo-EM 1.6 Å	2020	Not shown	Not tested	Liver, kidney, cervix, retina, skin, lung	Xie et al. [31]	7KFR

¹ Li and Samulski 2020 [32], Review; ² Ellis et al. 2013 [33], Supplementary Table S2; ³ Grimm et al. 2008 [34], Supplementary Table S2.