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. 2021 Jun 27;13(7):1251. doi: 10.3390/v13071251

Figure 4.

Figure 4

(A) Frameshifting in EMCV (and TMEV) is stimulated by a protein:RNA complex positioned at the leading edge of the ribosome when the decoding center is on the shift site. The viral encoded 2A protein, which is encoded 5′ of the shift site, binds to the 3‘ stem loop to stimulate frameshifting. (B) Frameshifting in PRRSV is stimulated by a protein:RNA complex that requires dimerization of the virally encoded nsp1B protein and the chromosomally encoded polyC binding protein which bind to the 3‘ stem loop to stimulate frameshifting.