Table 3.
Anti-schistosomal vaccine candidates.
| Antigen | Location | Target Species | Function | Vaccine Development Stage | References |
|---|---|---|---|---|---|
| Sm-TSP-2 | Tegument | S. mansoni | Maintains tegument creation and maturation in the adult worm | Phase I | [146] |
| Sj97 | Tegument of schistosomula and penetration glands of the cercariae | S. japonicum | Associated with resistance to infection and re-infection | Pre-clinical | [2] |
| Sm97 | Tegument and cercariae | S. mansoni | Offers protective immunity to the host | Pre-clinical | [147] |
| Sm-p80 | All developmental stages of S. mansoni | S. mansoni | Immune evasion | Pre-clinical | [148] |
| Sm29 | Tegument | S. mansoni | Protection against re-infection | Pre-clinical | [116] |
| SmKI-1 | Tegument and sub-shell region of eggs | S. mansoni | Inhibits host proteases; permits parasite survival | Pre-clinical | [71] |