Table 1.
Overview of the discussed shielding polymers and their main characteristics. Reactivity of the polymers was directed to amine- (–NH) or thiol- (–SH) groups, whereas the functionality describes the number of reactive groups per polymer (monofunctional = one reactive group; heterobifunctional = two different reactive groups; polyfunctional = many reactive groups). Bioresponsive polymers were coupled reversible (under physiological conditions) to the capsid.
| Abbreviation | Polymer | Reactivity | Functionality | Bioresponsive |
|---|---|---|---|---|
| ONp-HPMA | 4-nitrophenoxy-poly-N-(2-hydroxypropyl) methacrylamide | –NH | polyfunctional | no |
| mal-HPMA | maleimide-poly-N-(2-hydroxypropyl) methacrylamide | –SH | polyfunctional | no |
| OPSS-HPMA | orthopyridyl-disulfide-poly-N-(2-hydroxypropyl) methacrylamide | –SH | polyfunctional | yes |
| Next Generation HPMA | EC208 | –NH | polyfunctional | yes |
| T-MPEG | tresyl-monomethoxypolyethylene glycol | –NH | monofunctional | no |
| CC-MPEG | cyanuric chloride monomethoxypolyethylene glycol | –NH | monofunctional | no |
| SS-MPEG | succinimidyl succinate monomethoxypolyethylene glycol | –NH | monofunctional | no |
| T-MPEG-mal | tresyl-polyethylene-glycol-maleimide | –NH, –SH |
heterobifunctional | no |
| mal-PEG | maleimide-polyethylene glycol | –SH | monofunctional | no |
| SPA-PEG | succinimidyl propionate polyethylene glycol | –NH | monofunctional | no |